File:2019-nCoV to bat-SL-CoVZC45 spike protein comparison.png

Summary
Comparison of 2019-nCoV spike glycoprotein to spike protein of bat-SL-CoVZC45.

|--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| MFVFLVL-LPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSN MLFFLFLQFALVNSQCVNLTGRTPLNPNYTNSSQRGVYYPDTIYRSDTLVLSQGYFLPFYSNVSW-YYSLTTNNAATKRTDNPILDFKDGIYFAATEHSN |--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| IIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDG IIRGWIFGTTLDNTSQSLLIVNNATNVIIKVCNFDFCYDPYLSGYYH-NNKTWSIREFAVYSSYANCTFEYVSKSFMLNISGNGGLFNTLREFVFRNVDG |--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| YFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSET HFKIYSKFTPVNLNRGLPTGLSVLQPLVELPVSINITKFRTLLTIHRGDPMP--NN-GWTAFSAAYFVGYLKPRTFMLKYNENGTITDAVDCALDPLSET |--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| KCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADS KCTLKSLTVQKGIYQTSNFRVQPTQSVVRFPNITNVCPFHKVFNATRFPSVYAWERTKISDCIADYTVFYNSTSFSTFKCYGVSPSKLIDLCFTSVYADT |--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| FVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQP FLIRFSEVRQVAPGQTGVIADYNYKLPDDFTGCVIAWN---TAKQDVGNYF--YRSHRSTKLKPFERDLSSDENGVRTLSTYD---FNPNVPL--- |--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| TNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVIT EYQATRVVVLSFELLNAPATVCGPKLSTQLVKNQCVNFNFNGLKGTGVLTDSSKRFQSFQQFGKDASDFIDSVRDPQTLEILDITPCSFGGVSVIT |--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| PGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQ-SIIAYTMS PGTNTSLEVAVLYQDVNCTDVPTTIHADQLTPAWRIYATGTNVFQTQAGCLIGAEHVNASYECDIPIGAGICASYHTASILRST-SQKAIVAYTMS |--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| LGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFG LGAENSIAYANNSIAIPTNFSISVTTEVMPVSMAKTSVDCTMYICGDSIECSNLLLQYGSFCTQLNRALSGIAIEQDKNTQEVFAQVKQIYKTPPIKDFG |--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| GFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPF GFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGGISARDLICAQKFNGLTVLPPLLTDEMIAAYTAALISGTATAGWTFGAGAALQIPF |--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| AMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLIT AMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQESLTSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLIT |--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| GRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSN GRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYIPSQEKNFTTAPAICHEGKAHFPREGVFVSN |--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| GTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLI GTHWFVTQRNFYEPKIITTDNTFVSGNCDVVIGIINNTVYDPLQPELDSFKEELDKYFKNHTSPDIDLGDISGINASVVNIQKEIDRLNEVARNLNESLI |--10||--20||--30||--40||--50||--60||--70||--80||--90||-100| DLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT DLQELGKYEQYIKWPWYVWLGFIAGLIAIVMVTILLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT

Self made
 * Sources
 * Wuhan seafood market pneumonia virus isolate 2019-nCoV WHU01, complete genome
 * Bat SARS-like coronavirus isolate bat-SL-CoVZC45, complete genome


 * Edits
 * I have tweaked the alignment to show the SPRR insert at locations 681-684 based on this paper:
 * Sequence Analysis Indicates that 2019-nCoV Virus Contains a Putative Furin Cleavage Site at the Boundary of S1 and S2 Domains of Spike Protein - Z. Wo, February 18, 2020 (preprint)


 * Other versions