Talk:Wuhan coronavirus outbreak/Lab-leak theory

The improbable synonymous/non-synonymous pattern
Steven Quay notes an an improbable synonymous/non-synonymous pattern between the spike Protein gene sequences of RaTG13 and SARS-CoV-2. He then goes on to claim that RaTG13 is lab-created or a total fabrication. I find it more likely that RaTG13 is real and SARS-CoV-2 was synthesized in a lab.

But here is more: Would this indicate that SARS-CoV-2 is codon-optimized for humans? This paper says no, as the "codon usage is similar across these coronaviruses and is unlikely to explain the increased number of synonymous mutations."
 * An evolutionary portrait of the progenitor SARS-CoV-2 and its dominant offshoots in COVID-19 pandemic - Sudhir Kumar, & al. Molecular Biology and Evolution, May 4, 2021
 * ''In this mutation history, the ratio of nonsynonymous to synonymous changes (N/S) is 1.9, which is almost ten times larger than their ratio of 0.18 for the inferred proCoV2 and observed Bat CoV proteins.

-- Petri Krohn (talk) 17:54, 22 July 2021 (UTC)